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中枢神经系统生殖细胞肿瘤是儿童和青少年常见的中枢神经系统恶性肿瘤，好发于松果体区、鞍区或丘脑基底节区，少数病例可为多发病灶。其治疗方法和预后因肿瘤部位、临床表现及病理类型而异，治疗方案较为复杂。生殖细胞瘤（germinoma）是生殖细胞肿瘤中最常见的一种类型，纯生殖细胞瘤经手术活检确诊后，采用化疗联合放疗或单纯放疗均可获得良好疗效。中华医学会神经外科分会小儿神经外科学组基于国内外临床研究与实践经验，制定《中国儿童及青少年中枢神经系统纯生殖细胞瘤诊治指南》，涵盖3岁以上初发与复发患者的综合诊疗方案，旨在规范临床诊疗行为，进一步提升疗效。
Abstract：Central nervous system germ cell tumors are common malignant tumors in children and adolescents, often occurring in the pineal region, sellar region or basal ganglia-thalamus region, and in a few cases, multiple intracranial lesions may exist. Due to the differences in tumor location, clinical manifestations, and pathological types, treatment methods and prognosis vary. The treatment of central nervous system germ cell tumors is rather complex. The common treatment for pure central nervous system germ cell tumors is surgical biopsy to confirm the pathology, followed by chemotherapy combined with radiotherapy or radiotherapy alone, which can achieve good clinical outcomes. The Pediatric Neurosurgery Group of the Chinese Medical Association's Neurosurgery Branch has formulated the diagnosis and treatment guidelines for pure central nervous system germ cell tumors in Chinese children and adolescents based on domestic and international clinical research and experience. This guideline covers the integrated diagnosis and treatment plans for primary and recurrent central nervous system pure germinoma in patients over 3 years old, aiming to standardize the diagnosis and treatment of such patients in China and further improve their therapeutic efficacy.
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基本信息:
中图分类号:R739.4
引用信息:
[1]中华医学会神经外科分会小儿神经外科学组 ,马杰,陈忠平,等.中国儿童及青少年中枢神经系统纯生殖细胞瘤诊治指南（2026版）[J].中华神经外科疾病研究杂志,2026,20(02):1-7.
基金信息:
国家重点研发计划（2022YFC2705002）; 国家自然科学基金（8227102214）
2026-02-05
2026-02-05