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目的 本研究旨在探讨麻醉期间经皮穴位电刺激（TEAS）对脑血管内介入术后主要并发症的影响。方法 本研究为单中心随机对照试验。将拟行择期脑血管内介入手术的患者按照1∶1的比例随机分配到TEAS组和对照组，分别接受TEAS干预或假刺激。TEAS于麻醉诱导后至手术结束期间，在百会、内关和足三里穴施加。主要结局指标为住院期间术后主要并发症的发生率。次要结局指标包括术后3 d的疼痛视觉模拟量表（VAS）评分、40项恢复质量评分量表（QoR-40）评分和改良Rankin量表（mRS）评分，术后30 d和6个月的主要并发症发生率和死亡率，以及术后住院时间。结果 从2022年7月至2023年5月，166例患者被随机分组，154例完成了试验。意向性治疗分析表明，TEAS组住院期间主要并发症发生率为3.6%，对照组为6.0%[风险差（RD）为-2.4%,95%CI为-9.3%～4.5%,P=0.721]。TEAS组气管插管后即刻心率低于对照组（P=0.019）。其余次要指标两组差异均无统计学意义。结论 术中应用TEAS对脑血管内介入术后主要并发症的发生率无显著影响。
Abstract：Objective To investigate the effect of transcutaneous electrical acupoint stimulation(TEAS) during anesthesia on major complications after cerebral endovascular procedures. Methods This was a single-center, randomized controlled trial. Patients scheduled for elective cerebral endovascular procedures were randomly assigned in a 1:1 ratio to the TEAS group or the control group, receiving TEAS or no stimulation respectively. TEAS was applied at Baihui(GV20), Neiguan(PC6), and Zusanli(ST36) from anesthesia induction until the end of surgery. The primary outcome was the incidence of inhospital major complications after surgery. Key secondary outcomes included the Visual Analogue Scale(VAS) pain score,the 40-item Quality of Recovery(QoR-40) score, and the modified Rankin Scale(mRS) score at 3 days postoperatively, the incidence of major complications and mortality at 30 days and 6 months postoperatively, and the length of postoperative hospital stay. Results From July 2022 to May 2023, 166 patients were randomized, and 154 completed the trial. Intention-to-treat analysis showed that the incidence of in-hospital major complications was 3.6% in the TEAS group and 6.0% in the control group [risk difference(RD), 95% confidence interval(CI):-2.4%,-9.3% to 4.5%; P=0.721]. Heart rate immediately after tracheal intubation was significantly lower in the TEAS group than in the control group(P=0.019). No significant differences were found between the two groups in other outcomes. Conclusions Intraoperative TEAS does not significantly reduce major complications after cerebral endovascular procedures.
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基本信息:
中图分类号:R743
引用信息:
[1]曲凯丽,张敏娟,陈友军,等.经皮穴位刺激对脑血管内介入术后主要并发症的影响：一项随机临床试验[J].中华神经外科疾病研究杂志,2026,20(09):5-10.
基金信息:
国家自然科学基金资助项目（82371476,82293644）; 院级科研基金资助项目（2023LC2352,XJZT24LY15）
2026-09-08
2026-09-08